Best Movies Like Splice: Human Experiment Went Horribly Wrong

If you are here right now our guess is that you like movies like Splice and looking for other exciting movies with similar elements, like science fiction, genetic engineering, hybrids, and horror.

The story of Splice follows Clive Nicoli and Elsa Kast, a young and rebellious scientific couple, who attempt to introduce human DNA into their work of splicing animal genes.

The result is “Dren”, a hybrid creature that develops rapidly from a deformed baby to a beautiful human chimera. The relationship between Dren and her creators soon becomes problematic, as Dren matures and reveals new and dangerous attributes.

Well, if this is the case then you’ve come to the right place! The following list gathers the best movies to watch if you’re a Splice fan.

Our ranking system takes into account both how similar are the movies to Splice (mostly, common elements and atmosphere) and just how good the movies are.

Best Movies Like Splice

8 / 8

Species (1995)

Elements:  Action. Science Fiction. Horror.
Country: USA. Movie
Duration: 108 min.

movies like splice, #8, Species (1995)

When Earth scientists receive a transmission from an alien source with instructions on how to splice an alien DNA with human DNA. They go forward with the genetic experiment attempting to induce a female.

The result is a beautiful young woman named Sil who soon escapes from the secret government lab. Fearing she may mate with human males and produce offspring that could eliminate the human race, the government assembles a team to track and destroy Sil.

The team soon learns that they’re dealing with nothing short of a major planetary threat that will stop at nothing on its quest to mate and reproduce.

Species like Splice tell the story of a human hybrid experiment gone wrong. The movie depicts some good gory flow with a series of thrilling sequences and a cliffhanging climax. The team that chases Sil (Ben Kingsley, Michael Madsen) lifts Species above your average horror flick.

7 / 8

Event Horizon (1997)

Elements:  Science Fiction. Horror.
Country: USA. UK. Movie
Duration: 96 min.

Movies like Splice

In 2047, the rescue vessel Lewis and Clark are dispatched to investigate the mysterious reappearance of the Event Horizon.

It is a starship that disappeared during its maiden voyage to Proxima Centauri seven years previously. The rescue team is led by Captain Miller and is joined by Dr. William Weir, designer of the gravity drive systems on the Event Horizon.

Upon boarding the Event Horizon, the crew finds evidence of a massacre. They are soon sucked into a hellish dimension that makes their worse fears and regrets come to life. The ship is now possessed by a malevolent entity.

Event Horizon is an excellent horror science fiction film full of adventure and horror, led by an excellent assemble cast (Laurence Fishburne, Sam Neil, and Kathy Quinlan). 

6 / 8

28 Days Later (2002)

Elements:  Post-apocalypse. Horror.
Country: UK
Movie Duration: 113 min.

movies like splice

A highly contagious virus that causes people to become murderous and violent is unleashed in Great Britain. Soon the whole country is infected, resulting in societal collapse.

Twenty-eight days later, Jim wakes up from a coma in an abandoned emergency room in London. Confused, he wanders the corridors of the hospital in search of more people.

Finally, he turns to the city streets, calling for help. He is soon attacked by infected humans, but rescued by other survivors. Together they try to dodge both the infected and other survivors, who turn out to be just as murderous.

Director Danny Boyle (Trainspotting) paints a stunning and chilling picture of Britain after an attack of a deadly virus epidemic. 28 Days Later is easily one of the 5 best zombie films ever, although Boyle doesn’t consider it a zombie film.

5 / 8

Signs (2002)

Elements:  Science Fiction. Mystery. Thriller.
Country: USA.
Movie Duration: 106 min.

Movies like Signs

The story of Former Episcopal priest Graham Hess, who lost his religious faith and abandoned the church after his wife Colleen died in a tragic traffic accident.

One day, large crop circles appear in the Hess’ cornfield. His dogs start to go crazy and incomprehensible phenomena happen around the world.

It soon becomes clear that this is a worldwide alien invasion. Now Hess’s faiths are about to be tested.  

Signs is blessed with skilled acting (Mil Gibson, Joaquin Phoenix) and direction, and the soundtrack is extremely efficient. Director M. Night Shyamalan plays the audience like a piano, making us listen intensely even when there is nothing to be heard. And silence can be a scary thing!

4 / 8

Prometheus (2012)

Elements:  Science Fiction. Horror.
Country: UK. USA.
Movie Duration: 124 min.

Movies like Splice

Set in the late 21st century, the film follows archaeologist Elizabeth Shaw. Together with her partner Charlie Holloway and the crew of the spaceship USCSS Prometheus, They embark on a journey seeking the origins of humanity.

The ship’s crew travels in stasis while the android David monitors their voyage. When the crew arrives in a distant world, they discover an alien species of engineers that not only genetically designed humanity but also wanted to destroy it.

Director Ridley Scott slowly and cleverly builds the tension, until it explodes in the third act in a creepy self-surgery sequence that is sure to freeze your blood.

Splice is a film about human experiments gone terribly wrong, likewise, Prometheus. The film’s real star is David, the blond android, who seems to be developing his own set of attitudes towards human behavior – acting independently, seeking to break free.

3 / 8

Slither (2006)

Elements:  Science Fiction. Black comedy. Horror.
Country: USA.
Movie Duration: 95 min.

movies like splice

Wheesly is just like another small, quiet town in the heart of America, until one day malevolent, sentient extraterrestrial parasite land near the town inside a meteorite and starts terrorizing the friendly residents.

It infects Grant, the richest guy in town, taking over his body and absorbing his mind, changing his appearance into a grotesque, tentacled monstrosity.

Now, his wife, Starla, and local Police Chief Bill Pardy are tasked with trying to stop the alien parasite. And the epidemic of parasitic larvae that gradually turns all the townspeople into zombies and monstrous mutations with an appetite for raw meat.

Although the story may sound a bit worn-out, it actually works. The plot is humorous, likewise, there are effective actions and scenes that entertain us because of how stupidly the characters behave.

2 / 8

Mimic (1997)

Elements:  Science Fiction. Horror.
Country: USA.
Movie Duration: 106 min.

movies like splice

An epidemic is raging in New York, claiming hundreds of the city’s young children. The deadly disease (called “Strickler’s disease”) is spreading through cockroaches that reside in the city’s sewers.

In an effort to stop the epidemic, entomologist Dr. Susan Tyler uses genetic engineering to create what she calls the “Judas Breed” (half-mantis, half-termite hybrid) that releases an enzyme that kills the roaches.

Since the mutant bugs are all females, designed with a lifespan of only a few months, it is presumed that the new breed would die off after a single generation.

Soon the plague ends, but unfortunately, after three years it turns out that the mutant breed has survived and evolved into human-sized monsters that take on human form to kidnap and eat people in New York’s subway. Susan, her husband and a subway shoe shiner whose son was abducted by the bugs, set out to eradicate the bugs.

The film has been stylishly directed by Guillermo Del Toro, whose visual sense adds a certain texture that makes everything scarier and more effective. Actually, at times you might find yourselves sliding down in your seats.

1 / 8

The Fly (1986)

Elements:  Science Fiction. Psychological. Horror.
Country: USA. Movie
Duration: 96 min.

movies like splice

The Fly tells of a lonely and eccentric scientist Seth Brundle who invents a teleportation device. When Brundle tries to teleport himself, unaware that a housefly had entered the transmitter pod with him, he slowly turns into a fly-like hybrid creature.  

At first, Brundle exhibits increased strength, stamina, and sexual potency, but after a while, he experiences strange changes in his body and becomes arrogant and violent. Finally, he discovers the computer, confused by the presence of two lifeforms in the sending pod, fused him with the fly at the genetic level.

To fix the situation, Brundle installs a fusion program into the computer, planning to thin the fly genes in his body with human DNA. Of course, from there, things go even further downhill.

Splice is a horror sci-fi movie tribute to The Fly. Probably director David Cronenberg’s best movie, it’s a smart movie that methodically describes a human being who slowly turns into a fly in a torturous process. Actor Jeff Goldblum gives an excellent performance as Seth Brundle, who starts out as an enthusiastic scientist and then turns into an annoying, arrogant, and hated person. Perhaps the most interesting and best character Cronenberg has ever written.

More Movies like Splice

Resident Evil: Extinction (2007)
From Beyond (1986)
The Brood (1979)

Movies like Splice: Trailers

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